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目的观察专项干预对老年冠心病(CHD)合并牙周炎患者口腔、外周血及龈沟液(GCF)炎性指标影响。方法连续选择近期在解放军沈阳军区总医院心内科住院治疗的老年CHD合并牙周炎患者45例。入选对象随机分为口腔干预组(23例)和对照组(22例)。两组患者均接受了常规冠心病治疗,口腔干预组另接受了口腔专项干预治疗。治疗前后进行了口腔、外周血及GCF处炎性指标检测。结果两组患者治疗前各类口腔及牙周相关指标接近,治疗后口腔干预组的PD、CAL、M、SBI及OHI-S均明显好于治疗前及对照组同期结果 (P均<0.05);两组患者治疗前外周血炎性标识指标水平接近,两组患者治疗后外周血炎性标识指标水平均明显低于治疗前,同时,口腔干预组的IL-1β、IL-6、TNF-α和hs-CRP表达水平均显著低于对照组(P均<0.05);两组患者治疗前GCF处炎性标识指标水平接近,治疗后口腔干预组GCF处IL-1β、IL-6和TNF-α水平均显著低于治疗前及对照组同期结果 (P均<0.05~0.01)。结论专项干预可明确改善老年冠心病(CHD)合并牙周炎患者口腔、外周血及龈沟液(GCF)炎性指标。
Objective To observe the effect of special intervention on the inflammation index of oral, peripheral blood and gingival crevicular fluid (GCF) in elderly patients with coronary heart disease (CHD) complicated with periodontitis. Methods 45 consecutive elderly patients with chronic periodontitis admitted to Department of Cardiology, Shenyang Military Region General Hospital were selected in succession. The subjects were randomly divided into oral intervention group (23 cases) and control group (22 cases). Both groups received routine coronary heart disease treatment, oral intervention group also received special oral intervention. Before and after treatment of oral, peripheral blood and GCF at inflammatory markers. Results Before treatment, the indexes of oral cavity and periodontal were similar in both groups. PD, CAL, M, SBI and OHI-S in the oral intervention group were significantly better than those before treatment and in the control group (all P <0.05) The levels of IL-1β, IL-6 and TNF-α in the oral intervention group were significantly lower than those before the treatment in both groups, α and hs-CRP were significantly lower than those in the control group (all P <0.05). The levels of inflammatory markers in GCF before and after treatment were similar in both groups. After treatment, the levels of IL-1β, IL-6 and TNF -α levels were significantly lower than the same period before treatment and the control group (P <0.05 ~ 0.01). Conclusion Special intervention can clearly improve inflammatory markers of oral, peripheral blood and gingival crevicular fluid (GCF) in elderly patients with coronary heart disease (CHD) and periodontitis.