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目的观察碳酸利多卡因、盐酸利多卡因和甲磺酸罗哌卡因和盐酸罗哌卡因对孕大鼠离体子宫平滑肌收缩功能的影响。方法分离孕18～21 d SD大鼠的子宫平滑肌,制备成子宫肌条,采用累积给药法,用Medlab V5．5生物信号采集处理系统记录不同浓度(10-6、3×10-6、10-5、3×10-5、10-4、3×10-4mol／L)碳酸利多卡因、盐酸利多卡因和甲磺酸罗哌卡因与盐酸罗哌卡因对子宫平滑肌收缩力和收缩频率的影响。结果与基础值比较,3×10-4mol／L碳酸利多卡因使子宫平滑肌收缩力降低,10-4-3×10-4mol／L盐酸利多卡因、甲磺酸罗哌卡因和盐酸罗哌卡因使子宫平滑肌收缩力降低,3×10-4mol／L甲磺酸罗哌卡因和盐酸罗哌卡因使子宫平滑肌收缩频率降低(P<0．05),不同浓度盐酸利多卡因和碳酸利多卡因对子宫平滑肌收缩频率无影响;3×10-4mol／L甲磺酸罗哌卡因、盐酸罗哌卡因对子宫平滑肌收缩功能的抑制作用强于利多卡因。结论3×10-4mol/L碳酸利多卡因、盐酸利多卡因和甲磺酸罗哌卡因、盐酸罗哌卡因可抑制孕大鼠子宫平滑肌的收缩功能,等浓度罗哌卡因的抑制作用较利多卡因强。
Objective To observe the effects of lidocaine carbonate, lidocaine hydrochloride, ropivacaine mesylate and ropivacaine hydrochloride on contractile function of isolated uterine smooth muscle of pregnant rats. Methods The uterine smooth muscle of SD rats was isolated from 18 to 21 days of gestation. Uterine myoblasts were prepared and used to record uterine fibroids with different concentrations (10-6, 3 × 10-6, 10-5,3 × 10-5,10-4,3 × 10-4mol / L) lidocaine carbonate, lidocaine hydrochloride and ropivacaine mesylate and ropivacaine hydrochloride on uterine smooth muscle contractility And the impact of contraction frequency. Results Compared with the baseline values, 3 × 10-4mol / L lidocaine carbonate reduced uterine smooth muscle contractility, 10-4-3 × 10-4mol / L lidocaine hydrochloride, ropivacaine mesylate and hydrochloric acid Luo Contraction force of uterine smooth muscle decreased with lidocaine, contractile frequency of uterine smooth muscle decreased with 3 × 10-4mol / L ropivacaine mesylate and ropivacaine hydrochloride (P <0.05) And lidocaine carbonate had no effect on the contractile frequency of uterine smooth muscle. Ropivacaine mesylate and ropivacaine hydrochloride with 3 × 10-4mol / L showed more inhibitory effect on contractile function of uterine smooth muscle than lidocaine. Conclusion 3 × 10-4mol / L lidocaine carbonate, lidocaine hydrochloride, ropivacaine mesylate and ropivacaine hydrochloride can inhibit contractile function of uterine smooth muscle in pregnant rats, and the inhibition of ropivacaine at the same concentration More effective than lidocaine.