在过去20年诊断原发性系统性红斑狼疮(以下简称SLE)的患者中,有3—12％的病人可能是药源性狼疮综合征(以下简称DIL)。如美国约有50万人患SLE,而其中有几万人是由药物引起的狼疮综合征。现就DIL有关问题综述如下。一、引起DIL的药物早在1945年即有描述应用磺胺药、抗癫癎药后引起酷似急性狼疮的临床表现。之后逐渐涉及血清学变化及系统表现。有研究 Among the patients diagnosed with primary systemic lupus erythematosus (SLE) in the past 20 years, 3-12% of patients may be drug-induced lupus syndrome (hereinafter referred to as DIL). For example, about 500,000 people suffer from SLE in the United States, and tens of thousands of them are drug-induced lupus syndrome. Now on DIL related issues are summarized below. First, the drugs that cause DIL As early as 1945, there is a description of the application of sulfa drugs, anti-epileptic drugs caused the clinical manifestations of acute lupus. After gradual involvement of serological changes and systemic manifestations. Have research