论文部分内容阅读
目的:探讨糖化血红蛋白(HbAl)在妊娠糖尿病筛查中的临床价值。方法:采用全自动生化仪对正常对照组、正常妊娠组各50例及妊娠糖尿病(GDM)组36例进行了空腹血糖(FPG)、口服50 g葡萄糖筛查试验(GCT)、糖化血红蛋白(HbAlc)测定(正常对照组未做GCT)。结果:正常对照组与正常妊娠组比较FPG及HbAlc无差异(P>0.05);GDM组FPG、GCT、HbAlc与正常妊娠比较均明显增高,差别有显著性(P>0.01),GDM组FPG、GCT、HbAlc阳性率分别为38.9%、83.3%、80.6%。HbAlc在GDM筛查中敏感性、特异性、可靠性、阳性预测分别为80.6%、96%、89.5%、93.5%;HbAlc除敏感性比GCT稍低外,其实指标均高于FPG、GCT。结论:HbAlc检查方法快速、简便、实用、取血量少,不易受其它因素影响,随时可测定,可作为GDM诊断筛查的指标。
Objective: To investigate the clinical value of glycosylated hemoglobin (HbA1) in the screening of gestational diabetes mellitus. Methods: Fasting blood glucose (FPG), oral glucose 50 g (GCT), glycosylated hemoglobin (HbA1c) in normal control group, normal pregnancy group (n = 50) and gestational diabetes mellitus (n = ) (Normal control group did not do GCT). Results: FPG and HbAlc showed no significant difference between normal control group and normal pregnancy group (P> 0.05). The levels of FPG, GCT and HbAlc in GDM group were significantly higher than those in normal pregnancy (P> 0.01) GCT, HbAlc positive rates were 38.9%, 83.3%, 80.6%. The sensitivity, specificity, reliability and positive predictive value of HbA1c in GDM screening were 80.6%, 96%, 89.5% and 93.5%, respectively. HbA1c had higher sensitivity than FPG and GCT except for the lower sensitivity than GCT. Conclusion: HbAlc test method is rapid, simple and practical, less blood loss, less susceptible to other factors, can be measured at any time, can be used as an indicator of GDM diagnosis and screening.