【摘 要】
：
An experimental model of schizophrenia was established using dizocilpine (MK-801). Rats were intragastrically administered with Wendan decoction or clozapine fo
【机 构】
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Jiangxi University of Traditional Chinese Medicine,Affiliated Hospital of Jiujiang University of Jia
【基金项目】
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This study was sponsored by the Natural Science Foundation of China;Research Plan of Traditional Chinese Medicine of Jiangxi Province Department of Public Health;Jiangxi Provincial Youth Science Fund
论文部分内容阅读
An experimental model of schizophrenia was established using dizocilpine (MK-801). Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment.
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