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目的:了解EB病毒VCA-IgA与鼻咽癌临床表现的关系.方法:对梧州市肿瘤所门诊经病理确诊的鼻咽癌患者1868例,应用免疫酶法测定鼻咽癌病人血清中EB病毒VCA-IgA抗体.EB病毒VCA-IgA抗体测定结果与鼻咽癌患者的临床主要特征及分期进行分析.结果:EB病毒VCA-IgA抗体水平与鼻咽癌患者的性别无关;与患者各年龄组之间无显著差异;患者原发灶TO-T4其抗体水平有轻微上升,但无明显的波动;患者的临床分期Ⅰ～Ⅳ期根据病程的发展有逐渐升高的趋势;而早期(Ⅰ、Ⅱ)与晚期(Ⅲ、Ⅳ)期比较、颈部淋巴结N_0～N_3之间的比较有显著的差异.结论:结果分析提示EB病毒VCA-IgA抗体水平与鼻咽癌的发生及发展有密切关系.
Objective: To understand the relationship between Epstein-Barr virus (VCA-IgA) and the clinical manifestations of nasopharyngeal carcinoma.Methods: 1868 nasopharyngeal carcinoma patients diagnosed by pathology in Wuzhou were enrolled in this study. Enzyme immunoassay was used to detect the serum levels of Epstein-Barr virus VCA -IgA antibody.EB virus VCA-IgA antibody and nasopharyngeal carcinoma patients with clinical features and staging were analyzed.Results: EBV VCA-IgA antibody levels in patients with nasopharyngeal carcinoma has nothing to do with gender; and patients of all age groups There was no significant difference between the two groups. The antibody level of TO-T4 in patients with primary tumor increased slightly, but there was no obvious fluctuation. The clinical stage Ⅰ ~ Ⅳ of patients showed a gradually increasing trend according to the course of disease. ) Compared with those in advanced stage (Ⅲ, Ⅳ), there was a significant difference in N_0 ~ N_3 between cervical lymph nodes.Conclusion: The results suggest that the level of VCA-IgA antibody of Epstein-Barr virus is closely related to the occurrence and development of nasopharyngeal carcinoma.