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1975年Awasthi证明硒是人体的必需微量元素之后,关于硒的生物学效应研究,有关硒在人体营养和健康方面的作用,有了更进一步的了解。已知缺硒与肿瘤、心血管病、肝脏疾病、恶性营养不良等多种疾病有关,在我国已证实和地方病(克山病、大骨节病)的发生也有十分密切的关系。 大骨节病(KBD)是一种地方性骨关节病,发生于俄罗斯的西伯利亚东部、朝鲜北部及我国北方等地。在我国分布于黑龙江、吉林、辽宁、河北、内蒙、山西、山东、河南、陕西、甘肃、青海、四川、西藏等省区,病区呈一条由东北向西南走向的低硒地带。生活在病区的少年儿童日平均硒摄入量12.44μg,非病区为每日96.63μg,远远高于病区儿童;病区内少年儿童硒摄入量仅为建议供给量(每日40～240μg)下限值
After Awasthi proved that selenium was an essential trace element in human body in 1975, further study on the biological effect of selenium on the role of selenium in human nutrition and health has been made. It is known that lack of selenium is related to various diseases such as cancer, cardiovascular diseases, liver diseases and malnutrition. It has also been confirmed that there is a very close relationship between the occurrence of endemic diseases (Keshan disease and Kashin-Beck disease) in our country. Kashin-Beck disease (KBD) is a endemic osteoarthropathy that occurs in Russia’s eastern Siberia, northern Korea and northern China. It is distributed in the provinces of Heilongjiang, Jilin, Liaoning, Hebei, Inner Mongolia, Shanxi, Shandong, Henan, Shaanxi, Gansu, Qinghai, Sichuan and Tibet in China. The ward is a low selenium zone from northeast to southwest. Children living in the ward average daily intake of selenium 12.44μg, non-ward 96.63μg daily, much higher than the ward children; ward children within the area of intake of selenium is only the recommended supply (daily 40 to 240 μg) lower limit