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目的 :探讨KAI1基因与食管癌转移的关系。方法 :应用原位杂交法分析KAI1基因在有淋巴结转移和无淋巴结转移的食管癌组织中的表达。结果 :在有淋巴结转移和无淋巴结转移的食管癌组织中KAI1mRNA的表达未见显著差异 (P >0 0 5 ) ,且KAI1mRNA表达与食管癌的分化无关 (P >0 0 5 )。结论 :KAI1基因对食管癌转移的发生无抑制作用 ;KAI1基因的表达也与食管癌的分化无关。
Objective: To investigate the relationship between KAI1 gene and esophageal cancer metastasis. Methods: The expression of KAI1 gene in esophageal cancer tissues with or without lymph node metastasis was analyzed by in situ hybridization. Results: The expression of KAI1 mRNA in esophageal cancer tissues with lymph node metastasis and without lymph node metastasis showed no significant difference (P> 0.05), and the expression of KAI1 mRNA had no correlation with the differentiation of esophageal carcinoma (P> 0.05). Conclusion: KAI1 gene has no inhibitory effect on the metastasis of esophageal cancer. The expression of KAI1 gene is also not associated with the differentiation of esophageal cancer.