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研究了农药丙溴磷对人红细胞的毒性作用。采用Ｂｉａｌｓｃｈｅ试剂直接法测定人红细胞膜唾液酸（ＲＢＣｍ－ＳＡ）含量；采用ＤＴＮＢ直接法测定全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性。当丙溴磷反应终浓度在２×１０－４～２×１０－２ｍｏｌ／Ｌ时，ＲＢＣｍ－ＳＡ降低，并呈剂量－反应关系；同时，全血ＧＳＨ－Ｐｘ活性降低，与ＲＢＣｍ－ＳＡ降低基本呈平行关系。结果显示：丙溴磷对红细胞有明显毒性作用，这可能是其非胆碱能毒性作用的重要基础。
The toxic effects of pesticide profenofos on human erythrocytes were studied. The contents of sialic acid (RBCm-SA) in human erythrocytes were determined by direct method of Bialsche reagent. The glutathione peroxidase (GSH-Px) activity in whole blood was measured by DTNB direct method. RBCm-SA was decreased and the dose-response relationship was observed when the final concentration of profenofos-methyl was 2 × 10-4 ~ 2 × 10-2mol / L. Meanwhile, the activity of GSH-Px in whole blood was decreased and RBCm-SA was decreased Basically parallel relationship. The results showed that profenofos has a significant toxic effect on erythrocytes, which may be an important basis for its non-cholinergic toxicity.