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Clq肾病是一种免疫复合物(IC)介导的肾小球病变,患者的尿蛋白量常在肾病综合征(NS)范围。Jennette和Hipp首先报道15例年龄14～27岁的本病患者时使用这一名称。ClqNP在免疫荧光(IF)检查中都可见到非全身性系膜病变的肾小球肾炎。ClqNP与其它原因引起的NS不同,其特点为,IF可见系膜区形成明显的Clq沿着免疫球蛋白沉积,而无膜增殖性肾小球炎(MPGN)的特征性肾小球毛细血管壁损伤和SLE的临床表现。 15例ClqNP患儿年龄2～16岁,男女之比1∶2。其中3例持续肾小球炎患儿表现为中度蛋白尿、血尿和细胞管型;1例肾炎性肾病;9例特发性NS;
Clq nephropathy is an immune complex (IC) -mediated glomerular disorder in which patients often have a range of urinary protein levels in nephrotic syndrome (NS). Jennette and Hipp first reported the name of 15 patients with this disease, aged 14 to 27 years old. ClqNP can be seen in immunofluorescence (IF) examination of non-systemic mesangial lesions of glomerulonephritis. ClqNP is different from NS caused by other causes and is characterized by the fact that the apparent mesangial area of IF appears to deposit along immunoglobulin whereas the characteristic glomerular capillary wall without membrane proliferative glomerulitis (MPGN) Injury and clinical manifestations of SLE. 15 cases of ClqNP children aged 2 to 16 years old, male to female ratio of 1: 2. Three cases of persistent glomerulonephritis in children showed moderate proteinuria, hematuria and cell tube; 1 case of nephritic nephropathy; 9 cases of idiopathic NS;