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目的探讨胃癌患者HER-2的过表达及临床病理学意义。方法选取2013年1月至2014年6月在兰州大学第二医院收治的经病理确诊的胃癌患者共540例。IHC法检测胃腺癌患者中HER-2的表达,以改良Hercep Test评分标准进行HER-2免疫组化结果判读,用卡方检验分析HER-2蛋白在胃腺癌组织中的表达与临床病理学参数的相关性。结果540例患者平均年龄56.5岁,男女比例3.5:1。HER-2蛋白过表达(IHC3+)共88例,总过表达率为16.3%。胃癌患者HER-2蛋白的过表达与肿瘤发生部位、肿瘤分化程度、有无淋巴结转移、是否有神经血管侵犯有关(P<0.05),而与患者的性别、年龄、肿瘤大小、肿瘤浸润深度、TNM分期、有无远处转移无相关性(P>0.05)。结论胃癌患者HER-2蛋白总过表达率为16.3%。胃癌组织中HER-2蛋白的过表达与肿瘤发生部位、分化程度、有无淋巴结转移、是否有神经血管侵犯相关。
Objective To investigate the overexpression of HER-2 and its clinicopathological significance in patients with gastric cancer. Methods A total of 540 patients with pathologically diagnosed gastric cancer admitted to the Second Hospital of Lanzhou University from January 2013 to June 2014 were selected. IHC method was used to detect the expression of HER-2 in gastric adenocarcinoma. The Hercep Test score was used to interpret the results of HER-2 immunohistochemistry. The expression of HER-2 protein in gastric adenocarcinoma was analyzed by chi-square test and the clinicopathological parameters Relevance. Results 540 patients with an average age of 56.5 years old, male to female ratio of 3.5: 1. There were 88 cases of HER-2 overexpression (IHC3 +), the total overexpression rate was 16.3%. The overexpression of HER-2 protein in gastric cancer patients was associated with tumor location, tumor differentiation, lymph node metastasis and whether there was neurovascular invasion (P <0.05), but not with the gender, age, tumor size, depth of tumor invasion, There was no correlation between TNM stage and distant metastasis (P> 0.05). Conclusion The total over-expression of HER-2 protein in gastric cancer patients was 16.3%. The overexpression of HER-2 protein in gastric cancer is related to tumor site, degree of differentiation, lymph node metastasis, and whether there is neurovascular invasion.