十几年来,用药物改变机体的神经调节以治疗疾病的方法,受到了很大重视,并且有了极重要的发展。其中取得成就较早的是神经节阻滞药的化学合成和临床应用。Paton及Zaimis,及对神经节阻滞药曾有综述及专著发表。Langley首先发现烟碱有阻滞神经节的作用。但是由于它在阻断神经节以前对N-胆碱反应系统有兴奋作用,引起复杂的反应,因此不能用于临床。最早用于临床的神经节阻滞药是四乙铵(TEA),其碘盐称为Tetamonium(Etamon)。Burn及Dale在1914年即 For more than a decade, the use of drugs to change the body’s neuromodulation to treat diseases has received great attention and has been of great importance. Among the achievements made earlier is ganglioside chemical synthesis and clinical application. Paton and Zaimis, and ganglioside drugs have been reviewed and monographs published. Langley first found that nicotine blocks ganglion. However, it can not be used clinically because it has a complex response to the N-choline reaction system before it blocks the ganglion. The earliest clinical blocker for ganglia is tetraethylammonium (TEA), whose iodized salt is known as Tetamonium (Etamon). Burn and Dale were in 1914