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为了探讨慢性肾衰(CRF)病人血浆组胺和血甲状旁腺素(PTH)的变化,采用荧光法和放射免疫法,检测了27例CRF病人血浆组胺及血PTH含量。结果显示血浆组胺和血PTH明显增高,且两者呈直线正相关,提示血中PTH升高是引起血浆组胺升高的原因之一。17例组胺和PTH升高者均有明显的皮肤瘙痒,为临床应用组胺H_2受体阻滞药及补钙治疗尿毒症皮肤瘙痒提供了理论依据。
In order to investigate the changes of plasma histamine and parathyroid hormone (PTH) in patients with chronic renal failure (CRF), the levels of plasma histamine and blood PTH in 27 CRF patients were detected by fluorescence and radioimmunoassay. The results showed that plasma histamine and blood PTH was significantly increased, and the two were linearly correlated, suggesting that elevated blood PTH is one of the causes of plasma histamine. 17 cases of histamine and PTH were significantly elevated pruritus, for the clinical application of histamine H_2 receptor blockers and calcium treatment of uremic skin itch provide a theoretical basis.