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目的探讨替罗非班对ST段抬高型心肌梗死(STEMI)伴心律失常急诊经皮冠状动脉介入(PCI)治疗中心肌灌注及心功能的影响。方法选取平顶山市第二人民医院89例STEMI伴心律失常患者,随机分组,对照组44例于PCI术中冠脉注射氯化钠注射液治疗,观察组45例于PCI术中冠脉注射替罗非班治疗,观察比较两组治疗后TIMI心肌灌注分级(TMP)及治疗前后心功能指标[射血分数(EF)、心输出量(CO)及左室舒张末期内径(LVEDD)]变化情况。结果观察组TMP心肌灌注分级Ⅲ级所占比例为77.78%(35/45),高于对照组47.73%(21/44),差异具有统计学意义(P<0.05);治疗后观察组EF及CO均高于对照组,LVEDD低于对照组,差异具有统计学意义(P<0.05)。结论替罗非班可改善ST段抬高型心肌梗死伴心律失常患者心肌灌注水平及心功能。
Objective To investigate the effects of tirofiban on myocardial perfusion and cardiac function in patients with STEMI and emergency percutaneous coronary intervention (PCI). Methods 89 patients with STEMI with arrhythmia in Second People’s Hospital of Pingdingshan were randomly divided into control group (n = 44), coronary artery injection of sodium chloride injection (PCI), observation group (n = 45) The changes of TIMI myocardial perfusion grade (TMP) and the cardiac function indexes (ejection fraction, left ventricular end diastolic diameter and left ventricular ejection fraction) before and after treatment were observed and compared in both groups. Results The percentage of myocardial perfusion grade Ⅲ in TMP group was 77.78% (35/45), which was significantly higher than 47.73% (21/44) in control group (P <0.05). After treatment, EF and CO were higher than the control group, LVEDD lower than the control group, the difference was statistically significant (P <0.05). Conclusion Tirofiban can improve myocardial perfusion and cardiac function in patients with ST-elevation myocardial infarction and arrhythmia.