【摘 要】
：
目的研究不同可溶性的2种纳米硒化镉的半数致死量LD50和蓄积作用。方法昆明种小鼠48只,随机分为2个实验组和1个对照组。每种材料按100mg/kg、215mg/kg、464mg/kg、1 000mg/kg
【机 构】
：
华北煤炭医学院,秦皇岛外贸商检局煤炭检验中心,
论文部分内容阅读
目的研究不同可溶性的2种纳米硒化镉的半数致死量LD50和蓄积作用。方法昆明种小鼠48只,随机分为2个实验组和1个对照组。每种材料按100mg/kg、215mg/kg、464mg/kg、1 000mg/kg进行腹腔注射染毒,Horn氏法计算LD50。小鼠40只,随机分为2个实验组,按1/5LD50固定剂量法腹腔注射染毒,观察记录动物死亡数,并计算蓄积系数K。结果 2种纳米硒化镉的LD50分别为215mg/kg和464mg/kg;蓄积系数K分别2.6和4.8。结论纳米硒化镉随着可溶性的升高,急性毒性和蓄积毒性降低。
Objective To study the LD 50 and accumulation of two kinds of soluble cadmium selenide nanoparticles. Methods Kunming mice 48 were randomly divided into two experimental groups and a control group. Each material was injected intraperitoneally at doses of 100 mg / kg, 215 mg / kg, 464 mg / kg, and 1 000 mg / kg, and LD50 was calculated by Horn’s method. Forty mice were randomly divided into two experimental groups. The mice were injected intraperitoneally with a fixed dose of 1/5 LD50 to observe the number of animal deaths and calculate the accumulation coefficient K. Results The LD50 of the two kinds of CdSe nanoparticles were 215 mg / kg and 464 mg / kg, respectively. The accumulation coefficients K were 2.6 and 4.8, respectively. Conclusion With the increase of solubility of CdSe, the acute toxicity and accumulative toxicity decrease.
其他文献
【摘 要】目的：观察高龄孕妇孕中期补钙的临床疗效。方法：将90例高龄孕产妇随机分成2组，治疗组45例，自孕12周至28周每日补钙1．5g，对照组未口服钙剂。结果：两组经统计学分析比较，差异有显著性意义(p＜0.05)。结论：高龄孕妇孕中期补钙可以改善腰腿痛、腓肠肌痉挛，关节痛等症状。 【关键词】高龄孕妇；孕中期补钙 【中圖分类号】R714.2 【文献标识码】A 【文章编号】100
We investigated CD19+CD34+ and CD19+CD34- B cells from cord blood (CB) and typical patients with B cell lineage acute and chronic lymphocytic leukemia (B-ALL an
Inoculation with purified specific protein is usually the first step for preparation of monoclonal antibody (mAb).But it is quite difficult to obtain pure prote
前庭大腺囊肿是育龄妇女的一种常见疾病.我科采用微波对该病进行治疗与囊肿造口术相比较,取得了满意的效果.现将结果报告如下.
SKG mouse, as a model of spontaneous rheumatoid arthritis (RA) bred recent years, is similar to the patients with RA. We analyzed the clonotypes of T cell infil
患者,男,48岁.患者因饮酒后出现牙痛于2007年6月13日23时到我院就诊,医师诊断为牙周炎,给予:(1)5%葡萄糖注射液250 ml,青霉素(哈药集团制药总厂,批号A06120906)800万U静脉滴注.(2)甲硝唑注射液(宇斯药业有限责任公司生产,批号07042211)200ml静脉滴注。
【摘 要】目的：探讨食管胃瓣膜式吻合术在下段食管癌切除术后抗吻合口反流中的作用。 方法：2009年5月至2011年5月，对31例食管下段癌行癌肿切除，食管－胃肌瓣胃腔内瓣膜式吻合术，年龄34-76岁，男25例，女6例。其中3例食管下段癌行弓上吻合，余28例均行弓下吻合。结果：全组无近期手术死亡，无明显返酸、嗳气、烧心、胸痛等返流症状发生。术后8-14天对全部患者行上消化道造影，影像学表现吻合口处
The present study is aimed at studying the gene for TIMP-3, a mammalian tissue inhibitor, by constructing a recombinant eukaryotic cell vector for gene therapy