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结核性脑膜炎(下称结脑)并发蛛网膜炎,致脑水循环障碍预后不佳,是临床难题之一。本文对4例重症结脑在应用3～6 SHR Z P/15 HR P 化疗方案并激素治疗中,出现蛛网膜炎致粘连、梗阻,应用透明质酸酶治疗收到较理想的效果。给药方法是,皮下注射透明质酸酶1500U,每日1次,鞘内注射交替应用透明质酸酶1500U、1NH0.1和透明质酸酶1500U、1NH0.1、氟美松2～4 mg,每周3次,至椎管梗阻缓解。
Tuberculous meningitis (hereinafter referred to as knot brain) complicated by arachnoiditis, resulting in poor prognosis of cerebral water circulation disorder is one of the clinical problems. In this paper, 4 cases of severe tuberculous brain in the application of 3 ~ 6 SHR Z P / 15 HR P chemotherapy and hormone therapy, the occurrence of adhesions and obstruction of arachnoid inflammation, hyaluronidase treatment received more satisfactory results. Administered by subcutaneous injection of hyaluronidase 1500U, 1 day, intrathecal injection of alternating hyaluronidase 1500U, 1NH0.1 and hyaluronidase 1500U, 1NH0.1, dexamethasone 2 ~ 4 mg , 3 times a week, to ease spinal canal obstruction.