The complexity of the indoor environment brings great challenges to predict the electromagnetic radiation field of multiple antenna systems. Based on the Finite Difference Time Domain (FDTD) algorithm, using the mobile phone shielding device as the multiple antenna systems example, the mobile phone shielding device’s indoor electromagnetic radiation field is researched by measurment method and simulation method. The effectivity of prediction method is verified by comparing the prediciton results with the measurment results. About 80% of the error can be controlled less than dB. The quantitative research has certain guiding significance to the prediction of the multiple antenna systems radio wave propagation. The complexity of the indoor environment brings great challenges to predict the electromagnetic radiation field of multiple antenna systems. Based on the Finite Difference Time Domain (FDTD) algorithm, using the mobile phone shielding device as the multiple antenna systems example, the mobile phone shielding device’s indoor electromagnetic radiation field is derived by measurment method and simulation method. The effectivity of prediction method is verified by comparing the prediciton results with the measurment results. About 80% of the error can be controlled less than dB. to the prediction of the multiple antenna systems radio wave propagation.