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目的探讨患者血清视黄醇结合蛋白(RBP)和尿α1-微球蛋白(α1-MG)在妊娠糖尿病(GDM)早期肾损害诊断中的应用价值。方法选取GDM患者60例,正常孕妇60例,未孕妇女60例,应用免疫比浊法检测血清RBP和尿α1-MG水平。结果 (1)GDM组血清RBP、尿α1-MG水平均高于正常孕妇组和未孕妇女组,各组间差异均有统计学意义(P均<0.05);(2)正常孕妇中孕组、晚孕组、GDM中孕组、晚孕组血清RBP、尿α1-MG水平差异均有统计学意义(P均<0.05);(3)GDM组血清RBP、尿α1-MG水平呈正相关(r=0.712,P<0.05)。结论血清RBP、尿α1-MG是可以反映GDM早期肾损伤的实验室指标,联合检测血清RBP、尿α1-MG可以早期诊断GDM导致的肾功能损害,降低母婴并发症或围产期死亡率,具有重要的应用价值。
Objective To investigate the value of serum retinol binding protein (RBP) and urinary α1-microglobulin (α1-MG) in the diagnosis of early renal damage in gestational diabetes mellitus (GDM). Methods Sixty patients with GDM, 60 normal pregnant women and 60 non-pregnant women were selected. Serum RBP and urinary α1-MG levels were measured by immunoturbidimetry. Results (1) Serum levels of RBP and urinary α1-MG in GDM group were significantly higher than those in normal pregnant women and non-pregnant women (all P <0.05); (2) (P <0.05). (3) Serum RBP and urinary α1-MG levels were positively correlated with GDM group (P <0.05). The level of serum RBP and urinary α1-MG in GDM group were significantly higher than those in GDM group r = 0.712, P <0.05). Conclusions Serum RBP and urinary α1-MG are the laboratory indexes that can reflect the early renal injury of GDM. Combined detection of serum RBP and urinary α1-MG can early diagnose the renal dysfunction caused by GDM and reduce the maternal or infant complications or perinatal mortality , Has important application value.