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目的探讨尿激酶型纤溶酶原激活物(urokinase plasminogen activator,uPA)在子宫内膜异位症发病机制中的作用。方法应用免疫组织化学方法检测40例子宫内膜异位症患者异位内膜及在位内膜、30例正常子宫内膜组织(对照组)中uPA蛋白表达水平。结果 uPA蛋白主要定位于细胞质,异位内膜、在位内膜、对照组腺上皮细胞及间质细胞均表达uPA蛋白,且在血管内皮细胞呈阳性表达;异位内膜间质细胞uPA阳性表达率为85.0%,高于异位内膜腺上皮细胞(60.0%)(P<0.05),在位内膜间质细胞(57.5%)(P<0.05)及正常内膜间质细胞(40.0%)(P<0.05);uPA蛋白在异位内膜Ⅰ~Ⅱ期与Ⅲ~Ⅳ期的表达差异无统计学意义(P>0.05)。结论 uPA在异位内膜间质细胞的高表达促使其转移、黏附、侵袭、生长,导致子宫内膜异位症的发生、发展。
Objective To investigate the role of urokinase plasminogen activator (uPA) in the pathogenesis of endometriosis. Methods Immunohistochemistry was used to detect the expression of uPA protein in 40 cases of endometriosis patients with ectopic and eutopic endometrium and 30 cases of normal endometrium (control group). Results The uPA protein mainly located in the cytoplasm, ectopic endometrium, eutopic endometrium, glandular epithelial cells and stromal cells in the control group expressed uPA protein, and expressed in vascular endothelial cells; uPA positive ectopic endometrial stromal cells The expression rate of eutopic endometrial stromal cells (85.0%) was higher than that of ectopic glandular epithelial cells (60.0%) (P <0.05), eutopic endometrial stromal cells (57.5%) and normal endometrial stromal cells %) (P <0.05). There was no significant difference in the expression of uPA protein between stage Ⅰ ~ Ⅱ and stage Ⅲ ~ Ⅳ in ectopic endometrium (P> 0.05). Conclusion The high expression of uPA in ectopic endometrial stromal cells promotes the development, metastasis, adhesion, invasion and growth of endometriosis.