1941年Mackenzie等人在研究磺胺胍抗大鼠肠道菌群的作用时,偶然发现大鼠的甲状腺增生,抗甲状腺药物治疗从此开始。Astwood首先使用了“抗甲状腺药物”这一名词。硫脲类是常用的抗甲状腺药。其作用是抑制甲状腺摄碘后的有机化过程。药物本身作为甲状腺过氧化物酶的底物被碘化、降解,使氧化碘不能给合到甲状腺球蛋白上,从而抑制甲状腺激素的生物合成。丙基硫脲嘧啶(PTU)还抑制T_4在外周组织转化成T_3。PTU和他巴唑 1941 Mackenzie et al in the study of the role of sulfaguanidine in rat intestinal flora, occasionally found in thyroid hyperplasia, anti-thyroid medication began. Astwood first used the term “antithyroid drugs.” Thiourea is a commonly used anti-thyroid drug. Its role is to inhibit the thyroid iodine after the organic process. Drug itself as a substrate of thyroid peroxidase iodide, degradation, so that iodine can not be administered to the thyroglobulin, thus inhibiting thyroid hormone biosynthesis. Propylthiouracil (PTU) also inhibits the conversion of T_4 to T_3 in peripheral tissues. PTU and methimazole