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从肝动脉输入血管升压药可增加药物输送至结肠直肠肝转移灶,但作用时间短暂。实验观察延长输注时间对血流和药物输送的作用。取雄性HoodedLister鼠作实验,14天前已自门静脉种植1×106个同源性肿瘤细胞,在每只鼠肝表面生成2~5个约5~8mm肿瘤,共72只鼠,麻醉下剖腹.插管至?
Injection of vasopressors from the hepatic artery increases drug delivery to the colorectal liver metastases, but the duration of action is short. Experiments were performed to examine the effect of prolonged infusion time on blood flow and drug delivery. Male Hooded Lister rats were used for the experiment. Fourteen days ago, 1×106 homologous tumor cells were implanted from the portal vein. Two to five 5-8 mm tumors were generated on the liver surface of each rat. A total of 72 rats were under anesthesia and caesarean section. Intubation to?