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家兔最小致热原剂量(MPD)即致热阈的测定,是检验动物质量并用兔法检测样品热原质的基础。为了保证出厂药品符合药典规定的质量标准,我们定期用细菌内毒素国家标准样品为致热原,对本厂实验兔进行致热阈测定及动态观察,同时做了幼龄兔与老龄兔的敏感性比较
Rabbit minimum pyrogen dose (MPD) that is, the thermal threshold, is to test the quality of animals and the basis of the sample pyrogen test by the rabbit method. In order to ensure that the manufactured drug meets the quality standards stipulated in the Pharmacopoeia, we routinely use the national standard sample of bacterial endotoxin as pyrogen and conduct thermodynamic threshold measurement and dynamic observation of the experimental rabbit in our factory, meanwhile we do the sensitivity of the young rabbit and the aged rabbit Compare