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对46例10个月～3.5岁肺炎患儿采用放免法测定血栓素B_2(TXB_2)和6-酮-前列腺素F_(1α)(6-酮-PGF_(1α))的含量以及两比值(T/K)的变化。对30例患儿进行了治疗前后的自身比较,并对重型肺炎(肺炎合并心衰)患儿与普通型肺炎进行比较。结果显示,肺炎急性期的TXB_2、6-酮-PGF_(1α)及T/K值明显高于对照组(P<0.01),恢复期下降,治疗前后比较差异显著(P<0.01)。肺炎心衰时TXB_2、6-酮-PGF(1α)及T/K比值明显高于普通型肺炎。结果表明,前列腺素系统在小儿肺炎急性期,尤其足重型肺炎的发生发展进程中参与了体内病生理变化并起了一定的作用。
The levels of thromboxane B 2 (TXB 2) and 6-keto-PGF 1α (6-keto-PGF 1α) were measured by radioimmunoassay in 46 infants with pneumonia aged 10 months to 3.5 years. / K) changes. Thirty children were compared before and after treatment, and children with severe pneumonia (pneumonia complicated with heart failure) were compared with common pneumonia. The results showed that TXB 2, 6-keto-PGF 1α and T / K in the acute phase of pneumonia were significantly higher than those in the control group (P <0.01), and the recovery period was decreased. The difference was significant (P <0.01) before and after treatment. TXB 2, 6-keto-PGF (1α) and T / K ratio in patients with pneumonia were significantly higher than those in common type pneumonia. The results showed that the prostaglandin system plays an important role in the pathophysiological changes in the acute stage of childhood pneumonia, especially in the development and progression of severe foot pneumonia.