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阿莫曲坦(almotriptan,LAS-31416)化学名为3-[2-(二甲氨基)乙基]-5-(吡咯烷基-1-磺酰甲基)-1H-吲哚,是一个选择性5-HT1B/1D受体激动剂,对颅内血管5-HT1B/1D受体显示出高度特异的亲和力,而对外周动脉受体的亲和力很弱。阿莫曲坦对冠状动脉的致痉作用比其他5-HT1B/1D激动剂(如舒?
Almotriptan (LAS-31416) has the chemical name 3- [2- (dimethylamino) ethyl] -5- (pyrrolidinyl-1-sulfonylmethyl) Selective 5-HT1B / 1D receptor agonists exhibit a high degree of specific affinity for intracranial vascular 5-HT1B / 1D receptors, whereas their affinity for peripheral arterial receptors is poor. Almotriptan on the role of coronary spasm than other 5-HT1B / 1D agonists (such as Shu?