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目的:探讨确诊新型冠状病毒肺炎（COVID-19）患者和排除COVID-19患者的临床特征以及影像学改变。方法:选取上海交通大学附属第六人民医院及其金山分院2020年1—2月收治的24例疑似COVID-19患者为研究对象，对10例确诊病例及14例排除病例的临床特征以及影像学改变进行分析。结果:24例病例均为早期轻症，血气分析正常。确诊患者10例，其中男性5例。10例患者均有发热、乏力，体温37.5～38.5℃，4例有干咳。2例患者无明确流行病接触史，其余8例患者有流行病史，发病时间1～10 d。影像学改变有磨玻璃影（9例），病灶可为单侧（1例）或者双侧且病灶贴近胸膜为主（9例），有结节影（1例），无坏死灶出现，可合并有胸腔积液（1例）。14例排除COVID-19患者均有流行病接触史，发病时间1～13 d，其中12例有发热症状，其中体温>38.5℃的4例，体温37.3～38.5℃的8例，2例无发热症状，所有患者均有乏力症状，7例有干咳症状，2例有胸痛症状；影像学改变：4例患者出现磨玻璃影，病灶10例为单侧，4例为双侧，且病灶较散发，无坏死灶出现，无胸腔积液。结论:COVID-19患者并非都有直接的流行病学史。患者可能在不知情的情况下被感染。COVID-19的CT影像学并没有区别于其他病毒性肺炎的特殊表现。本组COVID-19患者中年人更多见。“,”Objective:To investigate the early clinical characteristics and radiographic changes in confirmed novel coronavirus pneumonia (COVID-19) and COVID-19 excluded patients.Methods:Twenty-four patients with suspected COVID-19 admitted to Shanghai Jiaotong University Affiliated Sixth People’s Hospital and Jinshan Branch Hospital between January and February, 2020 were enrolled in this research. Early clinical features and radiographic changes were analyzed in 10 confirmed COVID-19 patients and 14 COVID-19 excluded patients.Results:In the early stage, all 24 suspected patients had minor symptoms, and had normal blood gas analysis results. Of 10 confirmed COVID-19 patients, 5 patients were male. All the 10 patients had fever and fatigue, with body temperature between 37.5 and 38.5 °C. Only 1 patient had hacking cough. Two patients had no clear epidemiological exposure history, the other 8 had clear epidemiological exposure history, with a possible incubation period of 1-10 days. From CT imaging, lesions were characterized as ground glass shadow (n n=9), which could be unilateral (n n=1) or bilateral (n n=9), and were mainly close to the pleura (n n=9), with nodule shadow (n n=1) and without focal necrosis, and could combined with pleural effusion (n n=1). Among the COVID-19 excluded patients, all 14 patients had clear history of epidemic exposure, with an onset time of 1 to 13 days. Twelve patients had fever, including 4 patients with body temperature > 38.5 °C, 8 patients with body temperature bwteen 37.3-38.5 °C, and 2 patients without fever. All patients had fatigue, 7 patients had hacking cough and 2 patients had chest pain. From CT imaging, ground glass shadow appeared in 4 patients, lesions were unilateral in 10 patients and bilateral in 4 patients, and the lesions were relatively sporadic, without necrosis or pleural effusion.n Conclusions:Not all patients with COVID-19 have a direct epidemiology exposure history, some patients may be infected unknowingly. According to CT imaging, COVID-19 seems to have no special manifestations being different from other viral pneumonia. COVID-19 is more common among middle-aged people.