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众所周知,吸烟对人体健康有害,已经确认吸烟可以引发肺癌、肺气肿和慢性支气管炎等多种肺部疾病.但是,关于吸烟对肺部的直接损伤机制还不十分清楚.随着有关这方面研究的深入,近来发现吸烟与血管紧张素转换酶(ACE)活性之间存在着密切联系,吸烟能够引起血清中ACE活性发生改变,从而对吸烟的危害性有了进一步的了解. 血管紧张素转换酶,其生理功能主要是将血管紧张素Ⅰ转换成有生物活性的血管紧张素Ⅱ,同时对舒缓激肽还具有灭活作用.该酶主要在肺部产生,位于肺血管内皮细胞内.通过研究吸烟对血清ACE活性的影响.Mizuno等人发现吸烟后可导致人血清ACE活性在5分钟之内迅速升高,并且这种升高一直持续到吸
It is well-known that smoking is harmful to human health and smoking has been identified as causing many lung diseases such as lung cancer, emphysema and chronic bronchitis, but the mechanism of direct lung damage by smoking is not well understood. In recent years, there is a close relationship between smoking and the activity of angiotensin-converting enzyme (ACE), smoking can cause changes in ACE activity in serum, so as to further understand the dangers of smoking.Angiotensin conversion Enzymes, its physiological function is mainly the conversion of angiotensin Ⅰ into biologically active angiotensin Ⅱ, at the same time on the bradykinin also inactivation of the enzyme is mainly produced in the lungs, located in pulmonary vascular endothelial cells by To study the effect of smoking on serum ACE activity.Mizuno et al found that smoking resulted in a rapid increase in human serum ACE activity within 5 minutes and this increase continued until suction