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目的探讨四联疗法治疗小儿消化性溃疡伴幽门螺杆菌感染的临床效果。方法选取本溪钢铁集团(有限)公司总医院收治的消化性溃疡伴幽门螺杆菌(Hp)感染患儿78例为研究对象,采取随机数字表法分为观察组和对照组,各39例。对照组患者采取三联疗法治疗(克拉霉素、阿莫西林、奥美拉唑),观察组患者采取四联疗法治疗(奥美拉唑、铋剂、甲硝唑、克拉霉素),比较两组患者的临床治疗效果。结果观察组和对照组患者治疗的总有效率分别为94.9%、66.7%,观察组高于对照组,差异有统计学意义(P<0.05)。观察组患者的复发率为2.6%,低于对照组的10.3%,差异有统计学意义(P<0.05)。观察组和对照组不良反应发生率分别为12.8%、33.3%,差异有统计学意义(P<0.05)。观察组患者的根除率为87.2%,高于对照组的59.0%,差异有统计学意义(P<0.05)。结论四联疗法治疗小儿消化性溃疡伴Hp可以收到显著的疗效,较常规三联疗法更优秀,并且具有较高的安全性。
Objective To investigate the clinical effect of quadruple therapy on children with peptic ulcer associated with Helicobacter pylori infection. Methods Seventy-eight children with peptic ulcer infection of Helicobacter pylori (Hp) who were admitted to the General Hospital of Benxi Iron and Steel (Group) Co., Ltd. were selected as research object. The patients were divided into observation group and control group with 39 cases in each group. Patients in the control group were treated with triple therapy (clarithromycin, amoxicillin, and omeprazole) and patients in the observation group were treated with quadruple therapy (omeprazole, bismuth, metronidazole, clarithromycin) Group of patients with clinical treatment. Results The total effective rate of treatment in observation group and control group was 94.9% and 66.7%, respectively. The observation group was higher than the control group with statistically significant difference (P <0.05). The recurrence rate of observation group was 2.6%, lower than that of the control group (10.3%), the difference was statistically significant (P <0.05). Adverse reactions in observation group and control group were 12.8% and 33.3%, respectively, with significant difference (P <0.05). The eradication rate in the observation group was 87.2%, which was higher than that in the control group (59.0%), the difference was statistically significant (P <0.05). Conclusion The quadruple therapy for children with peptic ulcer associated with Hp can receive a significant effect, better than conventional triple therapy, and has high safety.