四联疗法治疗小儿消化性溃疡伴幽门螺杆菌感染的临床效果

来源 :中国药物经济学 | 被引量 : 0次 | 上传用户:pazixu
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的探讨四联疗法治疗小儿消化性溃疡伴幽门螺杆菌感染的临床效果。方法选取本溪钢铁集团(有限)公司总医院收治的消化性溃疡伴幽门螺杆菌(Hp)感染患儿78例为研究对象,采取随机数字表法分为观察组和对照组,各39例。对照组患者采取三联疗法治疗(克拉霉素、阿莫西林、奥美拉唑),观察组患者采取四联疗法治疗(奥美拉唑、铋剂、甲硝唑、克拉霉素),比较两组患者的临床治疗效果。结果观察组和对照组患者治疗的总有效率分别为94.9%、66.7%,观察组高于对照组,差异有统计学意义(P<0.05)。观察组患者的复发率为2.6%,低于对照组的10.3%,差异有统计学意义(P<0.05)。观察组和对照组不良反应发生率分别为12.8%、33.3%,差异有统计学意义(P<0.05)。观察组患者的根除率为87.2%,高于对照组的59.0%,差异有统计学意义(P<0.05)。结论四联疗法治疗小儿消化性溃疡伴Hp可以收到显著的疗效,较常规三联疗法更优秀,并且具有较高的安全性。 Objective To investigate the clinical effect of quadruple therapy on children with peptic ulcer associated with Helicobacter pylori infection. Methods Seventy-eight children with peptic ulcer infection of Helicobacter pylori (Hp) who were admitted to the General Hospital of Benxi Iron and Steel (Group) Co., Ltd. were selected as research object. The patients were divided into observation group and control group with 39 cases in each group. Patients in the control group were treated with triple therapy (clarithromycin, amoxicillin, and omeprazole) and patients in the observation group were treated with quadruple therapy (omeprazole, bismuth, metronidazole, clarithromycin) Group of patients with clinical treatment. Results The total effective rate of treatment in observation group and control group was 94.9% and 66.7%, respectively. The observation group was higher than the control group with statistically significant difference (P <0.05). The recurrence rate of observation group was 2.6%, lower than that of the control group (10.3%), the difference was statistically significant (P <0.05). Adverse reactions in observation group and control group were 12.8% and 33.3%, respectively, with significant difference (P <0.05). The eradication rate in the observation group was 87.2%, which was higher than that in the control group (59.0%), the difference was statistically significant (P <0.05). Conclusion The quadruple therapy for children with peptic ulcer associated with Hp can receive a significant effect, better than conventional triple therapy, and has high safety.
其他文献
清晨略带寒意的微风吹散最后一丝睡意.在这条熟悉的路上已经走过了四个年头.和周围形形色色赶着上班的人们一样,我也要开始我平淡而又充满挑战的一天.自从选择了护士这个行业
期刊
期刊
@@
目的探讨厄贝沙坦氢氯噻嗪早期联合美托洛尔治疗老年心力衰竭患者的临床效果。方法选取2014年7月至2015年4月沈阳市第九人民医院收治的103例老年心力衰竭患者作为研究对象,按
目的:探讨后腹腔镜输尿管切开取石术后的护理方法,积累相关工作经验。方法:选取2009年7月-2013年5月我院接受后腹腔镜输尿管切开取石术治疗的42例患者作为研究对象,所有患者均接
期刊
目的探讨百草枯(PQ)中毒的发病机制、临床特点及治疗方法,以降低死亡率。方法对2006-05-2010-08的86例口服PQ中毒患者的临床资料进行回顾性分析。结果 86例中15例存活,71例死
目的 观察自制中药雾化液对缓解留置胃管致咽喉部不适、口干及排痰不畅等症状的临床效果.方法 随机选取本院2007年8月至2009年5月临床使用留置胃管的120例患者为观察对象,其
期刊
@@
目的:探讨微创手术治疗高血压脑出血的护理方法和经验。方法对我院采用微创手术治疗高血压脑出血进行护理总结。结果出院时存活224例,生活自理128例,卧床不起16例,死亡8例。结论
期刊