目的探讨养血清脑颗粒联合盐酸氟桂利嗪胶囊治疗急性脑梗死伴头痛患者的疗效。方法 110例急性脑梗死伴头痛患者入院后随机分为两组,对照组(55例)给予盐酸氟桂利嗪胶囊治疗,5 mg/次,晚间服用;观察组(55例)给予养血清脑颗粒联合盐酸氟桂利嗪胶囊治疗,养血清脑颗粒4 g/次,3次/d;盐酸氟桂利嗪胶囊5 mg/次,晚间服用。疗程均为4周。依据两组疗效,治疗前和治疗后2、4周的头痛积分、日常生活能力(ADL)评分及治疗期间不良反应情况,评价养血清脑颗粒联合盐酸氟桂利嗪胶囊治疗急性脑梗死伴头痛患者的疗效。结果观察组治愈25例,显效19例,有效6例,有效率90.9%,对照组患者治愈18例,显效12例,有效13例,有效率78.2%,两者相比,差异有统计学意义(P<0.05)。治疗前,两组头痛程度积分和发作频率积分相比,无统计学差异;治疗后2、4周,两组患者头痛程度积分和发作频率积分均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组头痛程度积分和发作频率均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组ADL评分相比,无统计学差异;治疗后2、4周,两组ADL评分均明显提高,同组治疗前后比较差异有统计学意义(P<0.05);且观察组ADL评分高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组不良反应发生率无统计学差异。结论养血清脑颗粒联合盐酸氟桂利嗪胶囊对急性脑梗死伴头痛患者具有较好的治疗效果,能明显减轻患者头痛,减少头痛发作频率,提高患者日常生活能力,用药具有安全性。 Objective To investigate the curative effect of Yangxue Qingnao Granules combined with Flunarizine Hydrochloride Capsule on patients with acute cerebral infarction and headache. Methods One hundred and ten patients with acute cerebral infarction and headache were randomly divided into two groups. The control group (55 cases) was treated with Flunarizine Hydrochloride Capsule (5 mg once daily). The observation group (55 cases) Granules combined with flunarizine hydrochloride capsule treatment, Yangxue Qingnao particles 4 g / times, 3 times / d; flunarizine hydrochloride capsule 5 mg / time, taken at night. The course of treatment is 4 weeks. Based on the two groups of curative effect, headache score, 2,4-week headache score, daily living ability (ADL) score and adverse reactions during treatment, before and after treatment, evaluation of Yangxue Qingnao Granules and Flunarizine Hydrochloride Capsule in the treatment of acute cerebral infarction with headache Patient’s efficacy. Results The observation group was cured in 25 cases, effective in 19 cases, effective in 6 cases, the effective rate was 90.9%, 18 cases were cured in the control group, markedly effective in 12 cases, effective 13 cases, effective rate 78.2%, the difference was statistically significant (P <0.05). Before treatment, there was no significant difference between headache degree score and seizure frequency score in the two groups; headache degree score and seizure frequency score were significantly decreased in both groups at 2 and 4 weeks after treatment, with statistical difference (P <0.05). The integral of headache and frequency of attack in the observation group were lower than those in the control group (P <0.05). Before treatment, there was no significant difference in ADL score between the two groups; after two and four weeks after treatment, the ADL scores of the two groups were significantly increased, with statistical significance (P <0.05) before and after treatment; and ADL Score higher than the control group, the difference was statistically significant (P <0.05). During the treatment, there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Yangxue Qingnao Granules and Flunarizine Hydrochloride Capsule have a good therapeutic effect on patients with acute cerebral infarction and headache, and can significantly reduce the headache, reduce the frequency of headache attacks and improve the daily living ability of patients, and the medication is safe.