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动物模型和早期临床实践提示自身免疫性疾病(AID)可能是造血干细胞异常所致疾病;近年来应用造血干细胞移植治疗AID在国内外受到广泛关注,并在临床取得一定效果。尽管存在一些问题有待于进一步研究解决,造血干细胞移植仍不失为治疗难治及威胁生命的重症AID的一条新途径。本文综述了近年来国内外这方面的研究进展。
Animal models and early clinical practice suggest that autoimmune diseases (AIDs) may be caused by abnormalities of hematopoietic stem cells. In recent years, the application of hematopoietic stem cell transplantation for AID treatment has drawn wide attention both at home and abroad and has achieved some clinical results. Although there are some problems to be further studied and solved, hematopoietic stem cell transplantation is still a new way to treat refractory and life-threatening AID. This article summarizes the research progress in this area at home and abroad in recent years.