论文部分内容阅读
目的观察洛铂联合香菇多糖胸腔灌注治疗难治性恶性胸腔积液的疗效。方法入组治疗后复发的难治性恶性胸腔积液患者46例,分为2组。观察组22例治疗方案:胸腔置管后排净胸腔积液,将洛铂30 mg溶解于生理盐水50 m L中进行胸腔灌注,1周后灌注香菇多糖注射液4 mg+生理盐水20 m L。对照组24例治疗方案:每周1次于胸腔灌注香菇多糖注射液4 mg+生理盐水20 m L,直至胸腔积液完全引出,拔除引流管。2组治疗后评价疗效,同时观察毒副反应及对患者生活质量的影响。结果观察组总有效率为68.2%,生活质量明显改善率63.6%,均高于对照组的50.0%、37.5%(P均<0.05)。2组均未出现由于严重毒副反应而不得不终止治疗病例。结论洛铂联合香菇多糖序贯性胸腔灌注治疗难治性胸腔积液疗效肯定,毒副反应轻,值得临床推广。
Objective To observe the efficacy of lobaplatin combined with lentinan in the treatment of refractory malignant pleural effusion. Methods 46 cases of refractory malignant pleural effusion recurred after treatment were divided into two groups. In the observation group, 22 cases were treated with pleural effusion after thoracotomy. Thirty milligrams of lobaplatin was dissolved in 50 ml of normal saline for thoracic perfusion. One week later, levogliptin injection (4 mg) and normal saline (20 ml) were infused. Control group, 24 cases of treatment options: once a week in the pleural infusion of lentinans injection 4 mg + saline 20 m L, until the pleural effusion completely leads to removal of the drainage tube. Two groups were evaluated after treatment efficacy, while observing the side effects and quality of life of patients. Results The total effective rate was 68.2% in the observation group and 63.6% in the quality of life improvement, which were all higher than those in the control group (50.0%, 37.5%, P <0.05). Neither group had to discontinue the treatment due to severe side effects. Conclusion Losoplatin and lentinan sequential pleural perfusion for the treatment of refractory pleural effusion with positive effect, light toxicity, worthy of clinical promotion.