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目的研究先天性心脏病(CHD)患儿血浆硫化氢(H2S)含量与正常小儿有何差异,并探讨其病理生理学意义。方法先天性心脏病和对照组各9例,测定其心率、血压、肺动脉压及血浆H2S含量,分析CHD患儿与对照组血浆H2S含量的差异及其与肺动脉压力的关系。结果CHD患儿血浆H2S含量为(32.13±2.25)μmol/L,低于对照组的(43.69±2.05)μmol/L,差异有显著性(P<0.01)。血浆H2S含量与肺动脉压力呈明显负相关(r=-0.864P<0.05)。结论内源性H2S的下调可能在CHD继发肺动脉高压的发病过程中起重要作用。
Objective To investigate the difference of plasma hydrogen sulfide (H2S) levels in children with congenital heart disease (CHD) and its significance in normal children. Methods Nine patients with congenital heart disease and control group were enrolled in this study. Their heart rate, blood pressure, pulmonary arterial pressure and plasma H2S level were measured. The difference of plasma H2S level between CHD children and control group and its relationship with pulmonary artery pressure were analyzed. Results The plasma level of H2S in children with CHD was (32.13 ± 2.25) μmol / L, which was significantly lower than that of the control group (43.69 ± 2.05 μmol / L) (P <0.01). There was a negative correlation between plasma H2S level and pulmonary artery pressure (r = -0.864P <0.05). Conclusion The down-regulation of endogenous H2S may play an important role in the pathogenesis of CHD secondary to pulmonary hypertension.