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目的研究替格瑞洛对不稳定性心绞痛(UAP)患者经皮冠状动脉介入治疗(PCI)后心肌微循环及心功能的影响。方法选取2013年6月至2015年7月收治的不稳定性心绞痛患者72例,随机数字表法分组,各36例。所有患者均实施经皮冠状动脉介入术,对照组予以硫酸氢氯吡格雷治疗,观察组予以替格瑞洛治疗。比较两组治疗前后微循环阻力指数(IMR)值及心功能各项指标[左心室射血分数(LVEF)、左室舒张期容积(LVEDV)、左室收缩末期容积(LVESV)]水平。结果治疗后观察组IMR值明显低于对照组,差异有统计学意义(P<0.05);治疗后观察组LVEDV、LVESV水平低于对照组,且LVEF水平高于对照组,差异均有统计学意义(P<0.05)。结论替格瑞洛应用于不稳定性心绞痛患者经皮冠状动脉介入治疗中,能明显改善患者心功能及心肌微循环。
Objective To investigate the effects of ticagrelor on myocardial microcirculation and cardiac function after percutaneous coronary intervention (PCI) in patients with unstable angina pectoris (UAP). Methods Seventy-two patients with unstable angina pectoris who were admitted from June 2013 to July 2015 were randomly divided into three groups according to random number table (36 cases). All patients underwent percutaneous coronary intervention, the control group was treated with clopidogrel hydrogen sulfate, the observation group was treated with ticagrelor. The microcirculation resistance index (IMR) and the indexes of cardiac function [left ventricular ejection fraction (LVEF), left ventricular diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV)] were compared between the two groups before and after treatment. Results After treatment, the IMR in the observation group was significantly lower than that in the control group (P <0.05). After treatment, LVEDV and LVESV levels in the observation group were lower than those in the control group, and the LVEF level was higher in the observation group than in the control group Significance (P <0.05). Conclusion Ticagrelor in patients with unstable angina percutaneous coronary intervention can significantly improve cardiac function and myocardial microcirculation.