甘草酸铵系甘草(Glycyorhiga vralensis Fish)中主要有效成分甘草酸(Glycyorhigie acid)之铵盐,我们对甘草酸铵的免疫药理作用,特别是对变态反应及其炎症的影响进行了研究。 研究结果表明:甘草酸铵对角叉菜胶、组胺、PGE_2、制霉菌素引起的大鼠足肿胀及热烫肿均有明显的抑制作用。对PG的合成或释放、对组胺、PGE_2的致炎作用也有明显的抑制。抑制热烫肿,表明它可能抑制缓 Ammonium glycyrrhizinate is the ammonium salt of Glycyorhigie acid, which is the main active ingredient in Glycyorhiga vralensis Fish. We studied the immunopharmacological effects of ammonium glycyrrhizinate, especially on allergy and inflammation. The results showed that ammonium glycyrrhizinate significantly inhibited rat paw swelling and thermal swelling caused by carrageenan, histamine, PGE 2 and nystatin. There was also significant inhibition of the synthesis or release of PG and the pro-inflammatory effects of histamine and PGE 2 . Inhibition of hot swelling, suggesting that it may slow down