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目的比较口服和阴道给黄体酮胶丸-琪宁用于药物促排卵周期中黄体支持的作用。方法 2007年10月至2008年12月对江苏省淮安市妇幼保健院生殖中心97例因排卵障碍造成女性不孕的患者行128个周期的促排卵治疗,用药期间患者均经阴道B超监测卵泡发育,确定排卵日期,将排卵后的患者随机分为两组:对照组50例,共67个周期,口服给黄体酮胶丸-琪宁;研究组48例,共61个周期,阴道给药。两组均自排卵24h后给药行黄体支持;给药前后取血查孕酮,并随访药物副反应的发生率及临床妊娠率。结果两组黄体酮胶丸用药后和用药前比较,血孕酮均明显升高,具有显著差异性(P<0.01),两组不同途径用药方法治疗后孕酮值比较无显著性差异(P>0.01),临床妊娠率比较无显著性差异(P>0.01),口服给药组副反应的发生率较阴道给药组有显著升高(P<0.01)。结论阴道给黄体酮胶丸在促排卵周期中黄体支持的临床疗效与口服黄体酮相似,但是,阴道给药的副反应发生率较口服给药发生率低,是促排卵周期进行黄体酮支持的另一可供选择的给药途径。
OBJECTIVE To compare the effects of oral administration and vaginal administration of progesterone capsules - qilin on luteal support during ovulation induction cycles. Methods From October 2007 to December 2008, 97 cases of female infertility caused by ovulation disorder were treated with ovulation induction in 97 cycles of reproductive center of Huai’an City, Jiangsu Province, China. Patients were monitored by vaginal B- Ovulation date, the ovulation patients were randomly divided into two groups: the control group of 50 cases, a total of 67 cycles, oral administration of progesterone capsules - Qilin; study group 48 cases, a total of 61 cycles, vaginal administration . Luteal support was given 24 h after ovulation in both groups. Blood progesterone was taken before and after administration, and the incidence of side effects and clinical pregnancy rate were followed up. Results Progesterone was significantly increased in both groups (P <0.01) after treatment and before treatment, and there was no significant difference in progesterone levels between the two groups (P > 0.01). There was no significant difference in clinical pregnancy rate (P> 0.01). The incidence of side effects in oral administration group was significantly higher than that in vaginal administration group (P <0.01). Conclusions The clinical efficacy of vaginal administration of progesterone capsules in luteal phase during ovulation induction is similar to that of oral progesterone. However, the incidence of side effects of vaginal administration is lower than that of oral administration and progesterone support during ovulation induction Another alternative route of administration.