目前为止,对于各种骨内固定金属材料的研究结果差异很大。Doisy等于1894年报告铝材料对机体具有一定的异物刺激,但其电解毒性低,用于人体具有安全性。Zierold等将金、银、铝、铅、铜等多种金属材料置入犬的骨骼,结果发现铜周围有明显的组织变色,金、银、铝周围有明显的骨膜下骨增殖,铅未见特殊反应。Jones等将数个金属片埋入犬股 So far, the results for various bone fixation metal materials vary greatly. Doisy et al. Reported in 1894 that aluminum has some foreign body irritation on the body, but its electrolytic toxicity is low and it is safe for the human body. Zierold and other metal, such as gold, silver, aluminum, lead, copper and other dogs into the bone, and found that there were obvious tissue around the copper discoloration, gold, silver, aluminum around the significant subperiosteal bone proliferation, lead not seen Special reaction Jones and others buried several cans of canine metal