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目的评析神经节苷脂治疗新生儿中重度缺氧缺血性脑病的临床应用价值。方法 66例中重度缺氧缺血性脑病新生儿,随机分为观察组与对照组,每组33例。在支持治疗和对症治疗的基础上,观察组给予神经节苷脂治疗,对照组给予胞二磷胆碱针治疗,疗程均为10 d,观察比较两组疗效。结果观察组总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组治疗后新生儿神经行为评价量表(NBNA)评分高于对照组,差异具有统计学意义(P<0.05)。结论神经节苷脂治疗新生儿中重度缺氧缺血性脑病临床应用价值较高,值得临床推广应用。
Objective To evaluate the clinical value of ganglioside in the treatment of moderate and severe hypoxic ischemic encephalopathy in neonates. Methods Sixty-six neonates with moderate and severe hypoxic-ischemic encephalopathy were randomly divided into observation group and control group, with 33 cases in each group. On the basis of supportive treatment and symptomatic treatment, the observation group was treated with ganglioside, while the control group was treated with citicoline. The course of treatment was 10 days. The curative effect was observed and compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, with statistical significance (P <0.05). The NBNA scores of the observation group were higher than those of the control group after treatment, the difference was statistically significant (P <0.05). Conclusion Ganglioside treatment of neonates with moderate and severe hypoxic-ischemic encephalopathy clinical application of high value, worthy of clinical application.