大骨节病是一种病因尚未阐明的疾病。它是以关节软骨和骺板软骨的变性与坏死为基本病变的地方病。多见于青少年和儿童,成人中发病甚少。病情轻者关节增大、间有疼痛、运动失调,但仍能胜任一般劳动;重者四肢短小畸形,手不能握、腿不能蹲、走路摇摆、状如“鸭步”。此种病人在重病区中约有10～15％。大骨节病一般不影响寿命,智力和生育力亦不受影响。发病年龄一般在5～15岁,重病 Kashin-Beck disease is a disease that has not yet been elucidated. It is an endemic disease based on the degeneration and necrosis of articular cartilage and epiphyseal plate cartilage. More common in adolescents and children, very few adults. Slight increase in the joints, pain, movement disorders, but still capable of general labor; severe limb short deformity, hands can not grip, legs can not squat, walk swing, like a “duck step.” Such patients in the area of ​​about 10 to 15%. Kashin-Beck disease generally does not affect life expectancy, mental and fertility are not affected. The age of onset is generally 5 to 15 years old, seriously ill