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目的 观察类叶升麻苷对小鼠学习记忆能力的影响。方法 用东莨菪碱致小鼠记忆获得性障碍模型 ,以行为学实验 (跳台法、水迷路法 )、大脑皮层和纹状体乙酰胆碱酯酶活性和M受体的最大结合力为指标观察类叶升麻苷的作用。结果 在东莨菪碱致小鼠记忆障碍模型中 ,类叶升麻苷可延长跳台实验的平台停留期 ,并显著减少错误次数 ;在水迷路实验中可提高正确反应百分率 ;并能拮抗东莨菪碱所引起的大脑皮层乙酰胆碱酯酶的增高及皮层、纹状体M受体最大结合力的降低。结论 类叶升麻苷对东莨菪碱所引起的小鼠学习记忆能力障碍有改善作用 ,其作用机制可能与抑制乙酰胆碱酯酶活性和激动M受体的作用有关
Objective To observe the effect of euphrone on learning and memory ability in mice. METHODS: The scopolamine-induced mouse model of memory acquisition disorder was used to observe the leaf-shaped Cimicifuga by ethological experiments (jumping platform, water labyrinth method), acetylcholinesterase activity in cerebral cortex and striatum, and maximum binding capacity of M receptors as indicators. The role of glycosides. RESULTS: In the scopolamine-induced mouse model of memory impairment, ascotactyl can prolong the platform dwell period of the platform-skipping experiment and significantly reduce the number of errors; it can increase the percentage of correct responses in water labyrinth experiments; and can antagonize the brain caused by scopolamine. Cortical acetylcholinesterase increased and the cortical, striatum M receptor maximum binding force decreased. Conclusion Ascotretin improves the learning and memory abilities of mice induced by scopolamine. Its mechanism of action may be related to the inhibition of acetylcholinesterase activity and the stimulatory effect of M receptors.