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目的 :为探讨葡甘聚糖对脂肪肝大鼠高脂血症的影响。方法 :Wistar大鼠随机分为 6组 ,即正常对照组 (n =8、C) ,模型组 (n =8、M) ,易善力预防组 (n =8、A1)、葡甘聚糖预防组 (n =9、B1) ,易善力治疗组 (n =11、A2 )和葡甘聚糖治疗组 (n =9、B2 )。检测处理 2周和 4周末血清肝脏酶学 (ALT、AST)、血脂 (TG、TC)水平和肝组织脂肪变性程度。结果 :与C组比较 ,M组血清生化ALT、AST水平显著升高 [(2 5 6± 14 4 .7)U L ,(410 .9± 12 0 .5 )U L](P<0 .0 1)。与M组相比 ,B1、A2、B2组ALT水平显著下降 [(15 0 .3± 5 8.4 )U L ,(76± 6 5 .1)U L ,(5 3.2± 5 3.1)U L](P <0 .0 5 ) ,而AST水平无明显降低 (P >0 .0 5 ) ,甚或升高。与C组比较 ,M组血清脂质TC、TG显著升高 [(1.5±0 .90 )mmol L ,(3.5± 0 .4 1)mmol L]]。与M组相比较 ,A1、B1组血清TG、TC水平无明显下降 ,分别为 [(1.6 0± 1.4 1)mmol L ,(3.4 0± 0 .4 5 )mmol L],和 [(0 .99± 0 .5 5 )mmol L ,(3.6 0± 0 .38mmol L) ](P >0 .0 5 ) ,而A2组和B2组显著降低 (P <0 .0 5 ) ,分别为 [(0 .5 3± 0 .5 5 )mmol L ,(3.10± 0 .36 )mmol L]和 [(0 .4 7± 0 .36 )mmol L ,(2 .86± 0 .10mmol L) ]。肝病理组织学检查发现 ,M组肝小叶内肝细胞发生中、重?
Objective: To investigate the effect of glucomannan on hyperlipidemia in fatty liver rats. Methods: Wistar rats were randomly divided into 6 groups: normal control group (n = 8, C), model group (n = 8, M), Esss prevention group (n = 8, Prevention group (n = 9, B1), Essamycin treatment group (n = 11, A2) and glucomannan treatment group (n = 9, B2). Serum liver enzymology (ALT, AST), blood lipid (TG, TC) levels and hepatic steatosis were detected at 2 weeks and 4 weeks after treatment. Results: Compared with group C, the level of serum biochemical ALT and AST in group M was significantly higher than that in group C [(2.56 ± 14.4.7) UL, (410.9 ± 12.5) UL] (P <0.01 ). Compared with M group, the levels of ALT in B1, A2 and B2 groups were significantly lower than those in group B1 [(15 0 .3 ± 5 8.4) UL, (76 ± 6 5 .1) UL, (5 3.2 ± 5 3.1) 0. 05), but no significant decrease in AST level (P> 0.05), or even increased. Compared with group C, the levels of serum lipid TC and TG in group M were significantly increased [(1.5 ± 0.90) mmol L, (3.5 ± 0.41) mmol L]]. Compared with M group, the levels of TG and TC in A1 and B1 groups were not significantly decreased, which were ((1.6 ± 1.4 1) mmol L, (3.4 ± 0.45) mmol L] and [ 99 ± 0.55 mmol L, (3.6 ± 0.38 mmol L)] (P> 0.05), while A2 and B2 decreased significantly (P <0.05) 0 .5 3 ± 0.55) mmol L, (3.10 ± 0.36) mmol L] and [(0.474 ± 0.36) mmol L, (2.86 ± 0.10 mmol L)]. Histopathological examination of liver revealed that M group hepatic lobule hepatocytes occurred in mid-weight