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目的观察疏风解毒胶囊联合干扰素及利巴韦林治疗小儿手足口病的临床疗效和安全性。方法选取96例手足口病患儿,随机分为2组,各48例。对照组使用干扰素+利巴韦林治疗,观察组在对照组基础加用疏风解毒胶囊。观察患儿治疗前后临床症状、体征变化及不良反应发生情况,评价2组临床总疗效。结果治疗3天后,2组患儿症状均明显改善,组间差异有统计学意义(P<0.05);治疗5天后,观察组患儿出现疱疹例数少于对照组,组间差异有统计学意义(P<0.05)。治疗5天后,观察组总有效率89.6%,对照组72.9%,差异有统计学意义(P<0.05)。结论疏风解毒胶囊联合干扰素及利巴韦林治疗小儿手足口病疗效确切,且无药物不良反应。
Objective To observe the clinical efficacy and safety of Shufeng Jiedu Capsule in combination with interferon and ribavirin in the treatment of hand-foot-mouth disease in children. Methods Ninety-six children with hand-foot-mouth disease were selected and randomly divided into two groups (48 cases each). The control group treated with interferon + ribavirin, the observation group in the control group with Shufeng Jiedu capsule. Before and after treatment in children with clinical symptoms, signs and adverse reactions, evaluate the total clinical efficacy of two groups. Results After 3 days of treatment, the symptoms of both groups were significantly improved (P <0.05). After 5 days of treatment, there were fewer cases of herpes in the observation group than those in the control group. The differences between the two groups were statistically significant Significance (P <0.05). After 5 days of treatment, the total effective rate was 89.6% in the observation group and 72.9% in the control group, the difference was statistically significant (P <0.05). Conclusion Shufengjiedu capsules combined with interferon and ribavirin treatment of children with hand, foot and mouth disease curative effect is accurate, and no adverse drug reactions.