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[目的]探讨S100A4蛋白在结肠腺瘤和结肠癌中的表达及其临床意义。[方法]用免疫组化法检测S100A4在15例正常肠黏膜、80例结肠腺瘤和60例结肠癌中的表达。[结果]S100A4蛋白在正常肠黏膜中无表达,在结肠腺瘤中阳性率为16.25%,在结肠癌中阳性率为56.67%。[结论]S100A4与结肠腺瘤和结肠癌的发生发展密切相关,是预测结肠肿瘤进展的有用指标。
[Objective] To investigate the expression of S100A4 protein in colorectal adenoma and colon carcinoma and its clinical significance. [Method] The expression of S100A4 in 15 cases of normal intestinal mucosa, 80 cases of colon adenoma and 60 cases of colon cancer was detected by immunohistochemistry. [Results] The S100A4 protein was not expressed in normal intestinal mucosa, the positive rate was 16.25% in colon adenomas and 56.67% in colon carcinomas. [Conclusion] S100A4 is closely related to the occurrence and development of colorectal adenoma and colon cancer, which is a useful index for predicting the progress of colon cancer.