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目的探讨长期口服小剂量肠溶阿司匹林对缺血性卒中合并慢性胃炎的干预作用。方法将我院500例缺血性卒中合并慢性胃炎患者随机分为两组各250例,在常规治疗的基础上,观察组给予肠溶阿司匹林100mg,1次/d,对照组给予维生素E100mg,1次/d,观察两组脑出血、缺血性卒中、消化道出血和胃炎症状活动情况,有消化道出血和胃炎症状活动的患者均需行胃镜检查。结果观察组的缺血性脑卒中发生率明显低于对照组(P<0.05),脑出血、消化道出血和胃炎活动情况两组比较无统计学意义(P>0.05),胃镜复查显示两组胃黏膜病变情况相似。结论合并慢性胃炎的缺血性卒中的患者长期服用肠溶阿司匹林可以明显减低卒中的发生率,而脑出血和消化道症状的发生率并不增加。
Objective To investigate the long-term oral administration of small doses of enteric-coated aspirin on ischemic stroke with chronic gastritis intervention. Methods 500 patients with ischemic stroke and chronic gastritis in our hospital were randomly divided into two groups of 250 cases. On the basis of routine treatment, the patients in the observation group were given aspirin 100 mg once daily and the control group were given vitamin E 100 mg, Times / d, to observe the two groups of cerebral hemorrhage, ischemic stroke, gastrointestinal bleeding and gastritis symptoms, patients with gastrointestinal bleeding and gastritis symptoms are required gastroscopy. Results The incidence of ischemic stroke in the observation group was significantly lower than that in the control group (P <0.05), and there was no significant difference between the two groups in cerebral hemorrhage, gastrointestinal bleeding and gastritis (P> 0.05) Gastric mucosal lesions are similar. Conclusions Long-term administration of enteric-coated aspirin in patients with ischemic stroke complicated by chronic gastritis can significantly reduce the incidence of stroke, while the incidence of cerebral hemorrhage and gastrointestinal symptoms does not increase.