目的　探讨重组人促红素（ｒ Ｈ  Ｅ Ｐ Ｏ ）对慢性肾衰患者体内氧自由基及抗氧化酶活性的影响。方法　测定 １９ 例老年慢性肾衰尿毒症期患者 ｒ Ｈ  Ｅ Ｐ Ｏ 治疗前后血浆 Ｍ Ｄ Ａ 、 Ｓ Ｏ Ｄ 及红细胞 Ｇ Ｓ Ｈ  Ｐｘ 含量。结果　ｒ Ｈ  Ｅ Ｐ Ｏ 治疗后慢性肾衰病人 Ｍ Ｄ Ａ 含量降低， Ｓ Ｏ Ｄ 、 Ｇ Ｓ Ｈ  Ｐｘ 活性升高。结论　ｒ Ｈ  Ｅ Ｐ Ｏ 纠正肾性贫血同时，可清除体内氧自由基，提高抗氧化酶活性。 Objective To investigate the effect of recombinant human erythropoietin (r H  E P O) on oxygen free radicals and antioxidant enzymes in patients with chronic renal failure. Methods The levels of plasma M D A, S O D and erythrocytes G S H  Px in 19 elderly patients with chronic renal failure and uremia were measured before and after r H  EPO treatment. Results After treatment with r H  EPO, the levels of M D A and the activities of S O D and G S H  Px in patients with chronic renal failure were decreased. Conclusion r H  EPO correct renal anemia at the same time, can scavenge oxygen free radicals and improve antioxidant enzyme activity.