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目的探讨自身免疫性内耳病实验诊断方法及其对类固醇激素的治疗反应。方法以自制的AIED诊断试剂盒对不明原因感音神经性聋患者进行自身抗体检测,选择阳性病例作4周以上的类固醇激素治疗并观察病人的治疗反应。结果286例不明原因感音神经性聋患者中,初步判断为AIED病例112例,94例病人坚持了4周以上的皮质激素治疗,30.8%(29/94)病人听阈改善≥15dB,平均改善气导听力22.3±6dB;34例坚持了14周以上的疗程,55.9%(19/34)听阈改善≥15dB,平均改善气导听力28.6±7dB。结论自制的诊断试剂盒对诊断AIED具有帮助作用,AIED病人对类固醇激素治疗具有良好反应。
Objective To investigate the experimental diagnosis of autoimmune inner ear disease and its therapeutic response to steroid hormones. Methods Self-made AIED diagnostic kit was used to detect autoantibodies in patients with sensorineural deafness of unknown origin. Positive patients were selected for more than 4 weeks of steroid treatment and the patient’s response to treatment was observed. Results Among the 286 patients with sensorineural hearing loss of unknown reason, 112 patients were initially diagnosed as AIED, 94 patients were treated with corticosteroids for more than 4 weeks, 30.8% (29/94) patients had a hearing threshold improvement of 15 dB, and mean improvement of gas Guide hearing of 22.3 ± 6dB; 34 cases insisted for more than 14 weeks of treatment, 55.9% (19/34) threshold improvement of ≥ 15dB, average improvement of air conduction hearing 28.6 ± 7dB. Conclusion Self-made diagnostic kits help to diagnose AIED, and patients with AIED respond favorably to steroid treatment.