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对18例获得性低巨核细胞性血小板减少性紫癜(AATP)进行了临床分析。所有患者骨髓巨核细胞数均<6个/片(3cm×1.5cm),血小板数<50×10～3/L,均有不同程度的多部位出血。其中15例贫血者贫血程度与出血量成正比,9侧患者存在可能病因,3侧患者的PAIg及PAC_3阳性。该结果提示部分AATP的病因与某些药物、感染、辐射线及自身免疫性疾病有关,且循环中存在抗血小板抗体。认为AATP宜为阶段性诊断,对原因不明者应长期随访观察。
Eighteen cases of acquired low megakaryocytic thrombocytopenic purpura (AATP) were analyzed clinically. All patients had a large number of bone marrow megakaryocytes <6 / piece (3cm × 1.5cm), platelet count <50 × 10 ~ 3 / L, all with varying degrees of multi-site bleeding. Among them, anemia in 15 patients was directly proportional to the amount of bleeding, 9 patients had possible etiology, and 3 patients had positive PAIg and PAC_3. This result suggests that some of the causes of AATP are associated with certain medications, infections, radiation and autoimmune diseases, and the presence of circulating anti-platelet antibodies. AATP should be considered phased diagnosis, for unknown reasons should be followed up long-term observation.