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目的:通过检测PGE2在前列腺液中的含量,分析其与慢性非细菌性前列腺炎症状之间的相关关系。方法:选择泌尿外科门诊前列腺炎患者,以前列腺按摩前后“两杯法”(PPMT)筛出慢性非细菌性前列腺炎患者48名,年龄20~42岁,平均28.96±6.04岁。依据美国国立卫生院前列腺炎症状指数评分表(NIH-CPSI)进行评分。选择无临床症状、前列腺液常规检查正常的32名做对照,年龄20~39岁,平均28.19±6.73岁。检验前列腺液常规后,检测前列腺液中PGE2的含量,同时SPSS13.0统计软件包对测量数据进行统计学分析。结果:CNBP组前列腺液中平均每高倍镜视野下WBC计数与PGE2水平均高于正常对照组;CNBP患者前列腺液中PGE2水平与NIH-CPSI疼痛不适症状评分呈正相关(P<0.01)。与NIH-CPSI症状总评分呈正相关(P<0.01)。而CNBP患者前列腺液中WBC计数与PGE2水平和临床症状无明显相关性。结论:结果显示慢性非细菌性前列腺炎患者,疼痛或不适症状与前列腺液中PGE2表达水平明显升高呈正相关。慢性非细菌性前列腺炎患者,疼痛或不适症状的产生与PGE2的产生相关。
Objective: To detect the content of PGE2 in prostatic fluid and analyze its relationship with the symptoms of chronic non-bacterial prostatitis. Methods: Forty-eight patients with chronic nonbacterial prostatitis were screened by PPMT before and after prostate massage, aged from 20 to 42 years with an average of 28.96 ± 6.04 years. According to the National Institutes of Health prostatitis symptom index score (NIH-CPSI) score. Select no clinical symptoms, prostatic fluid routine examination of 32 normal controls, aged 20 to 39 years, mean 28.19 ± 6.73 years. Prostatic fluid routine test, detection of prostatic fluid PGE2 content, and SPSS13.0 statistical package for the measurement data for statistical analysis. Results: The average WBC count and PGE2 level in CNBP group were higher than those in normal control group. Prostatic fluid PGE2 level in CNBP group was positively correlated with NIH-CPSI pain discomfort score (P <0.01). And NIH-CPSI symptom score was positively correlated (P <0.01). There was no significant correlation between WBC count and PGE2 level and clinical symptoms in CNBP patients. CONCLUSIONS: The results show that patients with chronic non-bacterial prostatitis have a positive correlation with pain or discomfort and elevated PGE2 expression in prostatic fluid. Chronic nonbacterial prostatitis patients, pain or discomfort symptoms associated with the production of PGE2.