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目的了解过敏性紫癜(HSP)患儿血清和尿液中可溶性细胞间粘附分子-1(sICAM-1)、可溶性血管细胞粘附分子-1(sVCAM-1)的水平。探讨粘附分子在HSP发病机制中的作用。方法研究对象为2006年3月至2006年11月在首都儿科研究所附属儿童医院住院的40例HSP患儿,正常对照为同期的33例外科非感染性疾病患儿,检测其外周血及尿液中粘附分子sICAM-1、sVCAM-1的水平。结果(1)HSP组血清sICAM-1、sV-CAM-1水平显著高于对照组(P<0.05)。但在肾炎组与非肾炎组中差异无统计学意义(P=0.659,0.080)。(2)HSP组尿液中sICAM-1、sVCAM-1水平与对照组差异无统计学意义(P=0.479,0.164)。HSP患儿肾炎组尿液中sICAM-1、sVCAM-1水平分别高于非肾炎组和正常对照组,但差异均无统计学意义(P>0.05)。而肾炎组中病理分级较重患儿其尿中两种粘附分子水平均较高。结论HSP患儿血清sICAM-1、sVCAM-1水平升高,尿sI-CAM-1、sVCAM-1水平可能与HSP患儿肾脏病变程度有关。粘附分子的表达增加参与了HSP发病的病生理过程。
Objective To investigate the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in serum and urine of children with Henoch-Schonlein Purpura (HSP). To investigate the role of adhesion molecules in the pathogenesis of HSP. Methods The subjects were 40 HSP children hospitalized at the Children’s Hospital Affiliated to Capital Institute of Pediatrics from March 2006 to November 2006. The control group consisted of 33 children with non-communicable surgical diseases during the same period. The peripheral blood and urine Fluid adhesion molecules sICAM-1, sVCAM-1 levels. Results (1) The levels of serum sICAM-1 and sV-CAM-1 in HSP group were significantly higher than those in control group (P <0.05). However, there was no significant difference between nephritis group and non-nephritis group (P = 0.659,0.080). (2) The levels of sICAM-1 and sVCAM-1 in urine of HSP group were not significantly different from those in control group (P = 0.479,0.164). The levels of sICAM-1 and sVCAM-1 in nephritis group were higher than those in non-nephritis group and normal control group, but the difference was not statistically significant (P> 0.05). Nephritis group in the pathological grading of children with high levels of both urine adhesion molecules. Conclusions Serum levels of sICAM-1 and sVCAM-1 in children with HSP may be increased. The levels of sI-CAM-1 and sVCAM-1 may be related to the degree of renal disease in children with HSP. Increased adhesion molecule expression is involved in the pathogenesis of HSP pathogenesis.