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目的研究一清胶囊抗甲型H1N1流感病毒作用。方法采用小鼠气管内注入甲型流感病毒鼠肺适应株A/PR/8/34(H1N1)病毒液建立病毒感染小鼠模型,以肺指数、肺指数抑制率、小鼠累积死亡率为指标,评价一清胶囊体内抗甲型H1N1流感病毒作用。结果 7.3 g·kg?1一清胶囊(原生药)可降低病毒感染小鼠的肺脏指数(P<0.05)和小鼠感染病毒后7~9 d内的死亡率(P<0.01)。结论一清胶囊具有明显的抗甲型H1N1流感病毒作用。
Objective To study the effect of Yiqing Capsule against influenza A (H1N1) virus. Methods A mouse model of virus infection was established by injecting mouse lung adenovirus type A / PR / 8/34 (H1N1) into mice by intratracheal intratracheal instillation. Lung index, lung index inhibition rate and cumulative mouse mortality rate were used as indexes , Evaluate a clear capsule in vivo anti-influenza A (H1N1) virus effect. Results 7.3 g · kg -1 Yiqing Capsule (crude drug) could reduce the lung index (P <0.05) of virus infected mice and the mortality rate of mice within 7 ~ 9 d after infection (P <0.01). Conclusion Yiqing capsule has obvious anti-influenza A (H1N1) virus.