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肿瘤的生物学行为受到肿瘤微环境中的肿瘤细胞和基质细胞的调控[1]。现已了解在大多数实体瘤组织中存在固有免疫和适应性免疫细胞,如巨噬细胞、中性粒细胞、肥大细胞和淋巴细胞。这些细胞调节肿瘤内及癌旁组织的类炎症反应,在促进和/或抑制肿瘤进展中起着重要的作用[2]。目前,发现了一类分泌IL-17为特征的CD4+T细胞———Th17细胞,其在自身免疫性疾病和炎症中的研究,取得了重要发现,近来在肿瘤免疫研究中也受到了很大的重
The biological behavior of tumors is regulated by tumor cells and stromal cells in the tumor microenvironment [1]. It is now known that innate and adaptive immune cells, such as macrophages, neutrophils, mast cells and lymphocytes, are present in most solid tumor tissues. These cells regulate inflammatory responses in and around tumor tissues and play an important role in promoting and / or inhibiting tumor progression [2]. Currently, a class of CD4 + T cells characterized by the secretion of IL-17, Th17 cells, has been found important in the study of autoimmune diseases and inflammations and has recently been well-studied in tumor immunity studies Big weight