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目的优选麻黄最佳提取溶剂和提取方法。方法以麻黄提取物中麻黄碱含量为指标,考察水煎法、乙醇回流提取法的提取率,并结合药效学实验进行提取溶剂和提取方法的优选。结果麻黄醇提提取率为68.39%,水提提取率为62.16%,小鼠止咳、祛痰药效学实验2种工艺均有显著效果,麻黄水提方法祛痰效果更佳。结论水提方法生产更加经济简便,最终采用水提方法。
Objective To optimize the best extraction of Ephedra extract and extraction methods. Methods The content of ephedrine in ephedra extract was taken as an index to study the extraction rate of decoction and ethanol reflux extraction method, and to optimize the extraction solvent and extraction method in combination with pharmacodynamics experiment. Results The extraction rate of ephedrine was 68.39%, the extraction rate of water was 62.16%. The two methods of cough and expectorant pharmacodynamics in mice showed significant effects. The expectorant effect of ephedra extract was better. Conclusion The method of water extraction is more economical and more convenient, and finally the method of water extraction is adopted.